NEWS
Latest news from the Laboratory
Prof. David Lembo wins the European call HORIZON-CL4-2021-RESILIENCE-01 with the NANOBLOC® project
The European Commission communicated, on 4 August 2022, the allocation of a funding of 5,727,386 euros for the project "ANTIVIRAL, ANTIBACTERIAL & ANTIFUNGAL NANOCOATING PLATFORM (NANOBLOC®, 101057597)" within the European call HORIZON-CL4 -2021-RESILIENCE-01. The project, which involves the collaboration of 4 European universities and institutes and 5 industrial companies, has the objective of developing innovative antimicrobial, antifungal and antiviral coatings applicable to a wide variety of substrates (porous materials, fabrics, commonly used solid surfaces …) by means of ecological and industrially scalable technologies. The UNITO unit, directed by Prof. David Lembo, will study and validate the antiviral efficacy, possible toxicity and mechanism of action of the coatings produced in the project. The project started on January 1, 2023, and will last 3 years.
Prof. Manuela Donalisio wins funding from the 2022 Charity Fund of Banca Intesa Sanpaolo for the identification of a new antiviral drug against respiratory syncytial virus
The project “Identification and preclinical development of antiviral molecules to combat respiratory syncytial virus epidemics”, with Principal Investigator Prof. Manuela Donalisio, was financed for 99,000 euros as part of the national call for Charity Fund of the National Bank Intesa Sanpaolo. The project involves the collaboration of the Universities of Turin and Perugia and the involvement of expert external partners, and has the aim of identifying a new antiviral drug candidate against respiratory syncytial virus infections by combining innovative medicinal chemistry and computational biology approaches. The UNITO unit will study and validate the antiviral efficacy, possible toxicity and mechanism of action of the candidate molecules identified in the project. The project began on January 1, 2023, and ended on June 30, 2024.
Latest publications
Arduino, I., Francese, R., Civra, A., Feyles, E., Argenziano, M., Volante, M., Cavalli, R., Mougharbel, A.M., Kortz, U., Donalisio, M., Lembo, D. (2024). Polyoxometalate exerts broad-spectrum activity against human respiratory viruses hampering viral entry. Antiviral Research. 226:105897. https://doi.org/10.1016/j.antiviral.2024.105897
Sogari, A., Rovera, E., Grasso, G., Mariella, E., Reilly, N. M., Lamba, S., Mauri, G., Durinikova, E., Vitiello, P. P., Lorenzato, A., Avolio, M., Piumatti, E., Bonoldi, E., Aquilano, M. C., Arena, S., Sartore-Bianchi, A., Siena, S., Trusolino, L., Donalisio, M., Russo, M., Di Nicolantonio, F., Lembo, D., Bardelli, A. (2024). Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells. Cell Reports. Medicine, 101376. Advance online publication. https://doi.org/10.1016/j.xcrm.2023.101376
Luceri, A., Francese, R., Perero, S., Lembo, D., Ferraris, M., & Balagna, C. (2024). Antibacterial and Antiviral Activities of Silver Nanocluster/Silica Composite Coatings Deposited onto Air Filters. ACS Applied Materials & Interfaces, 16(3), 3955–3965. https://doi.org/10.1021/acsami.3c13843
Argenziano, M., Arduino, I., Rittà, M., Molinar, C., Feyles, E., Lembo, D., Cavalli, R., & Donalisio, M. (2023). Enhanced Anti-Herpetic Activity of Valacyclovir Loaded in Sulfobutyl-ether-β-cyclodextrin-decorated Chitosan Nanodroplets. Microorganisms, 11(10), 2460. https://doi.org/10.3390/microorganisms11102460
Francese, R., Peila, C., Donalisio, M., Lamberti, C., Cirrincione, S., Colombi, N., Tonetto, P., Cavallarin, L., Bertino, E., Moro, G. E., Coscia, A., & Lembo, D. (2023). Viruses and Human Milk: Transmission or Protection?. Advances in Nutrition (Bethesda, Md.), 14(6), 1389–1415. https://doi.org/10.1016/j.advnut.2023.08.007
Ma, T., Ma, X., Lin, Z., Zhang, J., Yang, P., Csupász, T., Tóth, I., Misirlic-Dencic, S., Isakovic, A. M., Lembo, D., Donalisio, M., & Kortz, U. (2023). Gallium(III)- and Thallium(III)-Encapsulated Polyoxopalladates: Synthesis, Structure, Multinuclear NMR, and Biological Activity Studies. Inorganic Chemistry, 62(33), 13195–13204. https://doi.org/10.1021/acs.inorgchem.3c01530
Maglione, A., Francese, R., Arduino, I., Rosso, R., Matta, M., Rolla, S., Lembo, D., & Clerico, M. (2023). Long-lasting neutralizing antibodies and T cell response after the third dose of mRNA anti-SARS-CoV-2 vaccine in multiple sclerosis. Frontiers in Immunology, 14, 1205879. https://doi.org/10.3389/fimmu.2023.1205879
Civra, A., Costantino, M., Ronchi, G., Pontini, L., Poli, G., Marinozzi, M., & Lembo, D. (2023). Identification of oxysterol synthetic analogs as a novel class of late-stage inhibitors of herpes simplex virus 2 replication. Antiviral Research, 215, 105634. https://doi.org/10.1016/j.antiviral.2023.105634
Arduino, I., Calvo, J., Rittà, M., Cabeza, S., Llobera, M., Lembo, D., Gayà, A., Donalisio, M. (2023). Impact of time-temperature combinations on the anti-Cytomegalovirus activity and biological components of human milk. Pediatric Research. https://doi.org/10.1038/s41390-023-02606-1
Luceri, A., Francese, R., Lembo, D., Ferraris, M., Balagna, C. (2023) Silver Nanoparticles: Review of Antiviral Properties, Mechanism of Action and Applications. Microorganisms. 11(3), 629. https://doi.org/10.3390/microorganisms11030629
